Protein Modification Reagents
Medchemexpress LLC Mal-PEG2-Val-Cit-PAB-OH | 2055041-38-6 | 99.5% | 618.68 g/mol | C29H42N6O9 | 5 MG
Mal-PEG2-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker featuring a maleimide group, a PEG2 spacer, a valine-citrulline dipeptide cleavable linker, and a para-aminobenzyl (PAB) self-immolative spacer. It is supplied as a solid for research use and is intended for use in ADC and PROTAC synthesis.
- Cleavable Val-Cit dipeptide for enzyme-triggered payload release.
- Maleimide functional group enables thiol conjugation to antibodies or payloads.
- PEG2 spacer improves solubility and flexibility of the linker.
- PAB self-immolative spacer enables payload release after enzymatic cleavage.
- High purity (99.49% by COA) and molecular weight ~618.68 g/mol.
Medchemexpress LLC 2,5-dioxopyrrolidin-1-yl 1-(4-(1,2,4,5-tetrazin-3-yl)phenyl)-3,19-dioxo-6,9,12,15-tetraoxa-22,23-... | 95.0% | 723.82 | C30H41N7O10S2 | 5 MG
Tetrazine-PEG4-SS-NHS is a cleavable PEG4 linker that features a tetrazine reactive group, a disulfide (SS) cleavable spacer, and an N-hydroxysuccinimide (NHS) ester for efficient bioconjugation and click chemistry applications.
- Cleavable disulfide spacer enables reductive release of payloads.
- Tetrazine group allows inverse electron demand Diels-Alder (iEDDA) click reactions.
- N-hydroxysuccinimide (NHS) ester provides amine-targeted conjugation chemistry.
- PEG4 spacer improves solubility and provides flexibility between conjugated partners.
- Typical purity 95.0% by NMR.
- Molecular weight 723.82, solid, purple to purplish red in color.
- Storage: powder at -20 °C; in solvent store at -80 °C (up to 6 months) or -20 °C (up to 1 month).
Medchemexpress LLC Dm1-PEG4-DBCO | 1198.79 | C63H80ClN5O16 | 1 MG
DM1-PEG4-DBCO is a drug-linker conjugate that links the microtubule inhibitor DM1 to a DBCO-PEG4-Ahx linker for use in antibody-drug conjugate synthesis and bioorthogonal conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Drug-linker conjugate for antibody-drug conjugate synthesis.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry.
- Molecular weight 1198.79 g/mol.
- Chemical formula C63H80ClN5O16.
- Available in small vials for research use, including 1 mg and 5 mg sizes.
Ambeed 1 9HFluoren9yl 3oxo2 7 10 13 1
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oic acid, 557756-85-1, 98%
Medchemexpress LLC DSPE-PEG 2000 | 892144-24-0 | 99.37% | (C2H4O)nC42H82NO10P | 50 MG
DSPE-PEG 2000 is a PEG polymer that contains DSPE and amine end groups. It can be utilized to create micelles that function as nanoparticles for drug delivery.
- PEG polymer containing DSPE and amine end groups.
- Can be used to form micelles.
- Suitable for nanoparticle drug delivery.
Medchemexpress LLC DBCO-PEG8-NHS ester | 2553412-88-5 | 98.3% | C42H55N3O14 | 50 MG
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing azide groups. This product is intended for research use only.
- PEG-based PROTAC linker
- Click chemistry reagent
- Features a DBCO group for SPAAC with azide-containing molecules
- Used in the synthesis of PROTACs
Medchemexpress LLC N-(2-(4-(3,5-dioxo-1,2,4-triazolidin-4-yl)-2-methoxyphenoxy)ethyl)-4,7,10,13-tetraoxahexadec-1-5-ynamide | 99.3% | 508.52 g/mol | C23H32N4O9 | 5 MG
PTAD-PEG4-alkyne is a cleavable four-unit polyethylene glycol (PEG) linker bearing an alkyne group for click chemistry and antibody-drug conjugate synthesis. It enables conjugation to azide-functionalized molecules via copper-catalyzed azide-alkyne cycloaddition and provides a hydrophilic, cleavable spacer for payload attachment.
- Contains terminal alkyne for CuAAC (click) conjugation.
- Four-unit PEG spacer provides hydrophilicity and cleavability for ADC applications.
- High purity (99.3%) and molecular weight approximately 508.52 g/mol.
- Available in small research pack sizes, for example 5 mg.
- Storage: powder at -20°C; in solvent: -80°C up to 6 months, -20°C up to 1 month.
Medchemexpress LLC N3-PEG3-VC-PAB-MMAF | 2757277-32-8 | 100.0% | 1352.62 | C66H105N13O17 | 25 MG
N3-PEG3-VC-PAB-MMAF is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines an azide-functionalized PEG3 spacer, a valine-citrulline (VC) cleavable linker with a para-aminobenzyl (PAB) self-immolative spacer, and the tubulin inhibitor MMAF to enable click chemistry conjugation and controlled payload release.
- Azide-functionalized PEG3 spacer for click chemistry conjugation.
- VC-PAB cleavable linker enabling enzymatic release of payload.
- Includes MMAF payload for tubulin inhibition in ADC constructs.
- White to off-white solid with high purity suitable for research use.
- Available in small milligram pack sizes for synthesis workflows.
Medchemexpress LLC Biotin-PEG4-NHS ester | 459426-22-3 | 99.6% | C25H40N4O10S | 100 MG
Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein, enabling selective degradation of target proteins.
- Biotin-labeled, PEG-based linker
- Utilized in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC M-PEG-NHS ester (MW 5000) | 92451-01-9 | 95.0% | (C2H4O)nC7H9NO5 | 100 MG
m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound facilitates the degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system. It has an average molecular weight of 5000 and appears as a white to off-white solid. This product is for research use only.
- Peg-based protac linker
- Used in the synthesis of protacs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Average molecular weight of 5000
- White to off-white solid appearance
- For research use only
Medchemexpress LLC T-Boc-N-amido-PEG15-Br | 3012589-40-8 | 98.0% | C37H74BrNO17 | 50 MG
t-Boc-N-amido-PEG15-Br is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This product is for research use only.
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Designed to selectively degrade target proteins
- For research use only
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.7% | C16H29NO6 | 250 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves are designed with two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the protein of interest, utilizing the intracellular ubiquitin-proteasome system for selective protein degradation.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Echelon Biosciences Research Labs Pancreatic Elastase Substrate - 5 mg, CAS#: 52299-14-6
Pancreatic Elastase Substrate - 5mg , Succinyl-Ala-Ala-Ala-pNA Category/Application: Enzyme Substrates This item is non returnable
Apexbio Technology LLC EdU Flow Cytometry Assay Kit (Cy5), 100 tests
EdU Flow Cytometry Assay Kit (Cy5) is a sensitive and reliable way to detect and quantify cell proliferation in mammalian cells. It is optimized for flow cytometry. It is a better alternative to traditional BrdU (bromodeoxyuridine). Other sizes are also available. Please inqury us for quote.